antinociceptive effect of curcumin, an effective constituent of turmeric, in diabetic rats and evaluation of the involvement of lipid peroxidation

Authors

mehrdad roghani

tourandokht baluchnejadmojarad

abstract

objective: this study was designed to investigate the antinociceptive effect of curcumin in diabetic rats by using the formalin and hot tail immersion tests. methods: wistar rats were divided into the following six groups:  control; curcumin-treated control (50 mg/kg); diabetic; sodium salicylate (ss)-treated diabetic; and two curcumin-treated diabetic groups (10 and 50 mg/kg). curcumin was administered seven days after streptozotocin injection for a total of five weeks. results: high-dose curcumin treatment of diabetic rats reduced the pain score in both acute and chronic phases of the formalin test (p

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Journal title:
modares journal of medical sciences: pathobiology

Publisher: tarbiat modares university

ISSN 1562-9554

volume 15

issue 1 2012

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